Stannous chloride dihydrate → 4'-Amino-N-isopropylbiphenyl-4-sulfonamide

HRID 1661146Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1661146
O.O.[Sn](Cl)Cl.[CH:6]([NH:9][S:10]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][C:22]([N+:25]([O-])=O)=[CH:21][CH:20]=2)=[CH:15][CH:14]=1)(=[O:12])=[O:11])([CH3:8])[CH3:7]>CN(C=O)C>[NH2:25][C:22]1[CH:23]=[CH:24][C:19]([C:16]2[CH:17]=[CH:18][C:13]([S:10]([NH:9][CH:6]([CH3:8])[CH3:7])(=[O:12])=[O:11])=[CH:14][CH:15]=2)=[CH:20][CH:21]=1

Komponenten

4

Edukt 2

HCID 61436Stannous chloride dihydrateHCID 59694089N-Isopropyl-4'-nitrobiphenyl-4-sulfonamide

Produkt 1

HCID 596940904'-Amino-N-isopropylbiphenyl-4-sulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

288.8 mg (1.28 mmol) of tin(II) chloride dihydrate are added to a solution of 100 mg (0.26 mmol) of N-isopropyl-4′-nitrobiphenyl-4-sulfonamide (Example 11A) in 2.0 ml of DMF. After 18 h at room temperature, the reaction mixture is purified by preparative HPLC. The product fractions are concentrated in vacuo and dried under high vacuum. 47 mg (63.2% of theory) of the title compound are obtained.

Aufarbeitung

  1. customthe reaction mixture is purified by preparative HPLC
  2. concentrationThe product fractions are concentrated in vacuo
  3. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-116632d1b82049ba8ef5dd61525ab26d
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08030329B2

Notizen zur Reaktion

Wird geladen…