Sodium hydride → HCID 24955304, Verbindung

HRID 1661466Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1661466
[CH3:1][C@@H:2]1[C@@H:4]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:3]1[S:11]([CH3:14])(=[O:13])=[O:12].[F:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]2[C:30]3[C:25](=[CH:26][C:27]([SH:31])=[CH:28][CH:29]=3)[CH:24]=[N:23]2)=[CH:18][CH:17]=1.[H-].[Na+]>C1COCC1>[F:15][C:16]1[CH:17]=[CH:18][C:19]([N:22]2[C:30]3[C:25](=[CH:26][C:27]([S:31][C@H:4]([C:5]4[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=4)[C@@H:2]([NH:3][S:11]([CH3:14])(=[O:13])=[O:12])[CH3:1])=[CH:28][CH:29]=3)[CH:24]=[N:23]2)=[CH:20][CH:21]=1

Komponenten

5

Edukt 3

HCID 24758Sodium hydrideHCID 16112501HCID 16112501, VerbindungHCID 593397121-(4-Fluorophenyl)-1H-indazole-5-thiol

Produkt 1

HCID 24955304HCID 24955304, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To (2R,3R)-2-methyl-1-(methylsulfonyl)-3-phenylaziridine (38a, 0.03 g, 0.14 mmol) in THF (4 ml) was added 1-(4-Fluorophenyl)-1H-indazole-5-thiol (37c, 0.038 g, 0.16 mmol) and sodium hydride (5.11 mg, 0.21 mmol) on an ice bath with stirring. The ice bath was removed and the mixture was stirren at room temperature over night. The solvent was removed and the mixture was purified on HPLC. Yield 0.007 g (11%).

Aufarbeitung

  1. customThe ice bath was removed
  2. waitthe mixture was stirren at room temperature over night
  3. customThe solvent was removed
  4. customthe mixture was purified on HPLC

Quellen und Nachweise

ORD-Eintrag
ord-e8f7abd7afdf4d90b628df57a5e0b1e0
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08030340B2

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