Thionyl Chloride → 2-Methoxypyridine-4-carbonyl chloride
Reaktionsgleichung
S(Cl)([Cl:3])=O.[CH3:5][O:6][C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][N:15]=1)[C:10](O)=[O:11]>C1(C)C=CC=CC=1>[CH3:5][O:6][C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][N:15]=1)[C:10]([Cl:3])=[O:11]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 80 °C
Versuchsvorschrift
Thionyl chloride (30.0 mL, 0.39 mol) was added to a suspension of 2-methoxy-isonicotinic acid (15.0 g, 97.9 mmol) in anhydrous toluene (150 mL). The mixture was heated at 80° C. under nitrogen for 3 hours, cooled to room temperature and filtered. The filtrate was concentrated in vacuo to afford the title compound 7.7 g (46% yield).
Aufarbeitung
- temperaturecooled to room temperature
- filtrationfiltered
- concentrationThe filtrate was concentrated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-fa87cee453c74028962bd64ba9e7a046
- Quelldatensatz
- uspto-grants-2011_10
- Patentnummer
- US08030500B2
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