(4-Bromopyridin-2-yl)methanol → 4-Bromopyridine-2-carbaldehyde

HRID 1662192

Reaktionsgleichung

Reaktionsgleichung von HRID 1662192
[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][OH:9])[CH:3]=1>C(Cl)(Cl)Cl.[O-2].[Mn+4].[O-2]>[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH:8]=[O:9])[CH:3]=1

Komponenten

4

Edukt 1

HCID 14761462(4-Bromopyridin-2-yl)methanol

Produkt 1

HCID 147614724-Bromopyridine-2-carbaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6212ChloroformLösungsmittel

Versuchsvorschrift

Manganese(IV) oxide (22.19 g, 255.29 mmol) was added to a solution of (4-bromopyridin-2-yl)methanol (4.00 g, 21.27 mmol) in chloroform (80 mL) and the reaction mixture was stirred under reflux for 45 min. After the mixture had cooled to room temperature the solids were removed by filtration through a pad of Celite®. The solvent was removed in vacuo and the residue (3.96 g, quant.) was used without further purification in the next step.

Aufarbeitung

  1. temperatureunder reflux for 45 min
  2. customwere removed by filtration through a pad of Celite®
  3. customThe solvent was removed in vacuo
  4. customthe residue (3.96 g, quant.) was used without further purification in the next step

Quellen und Nachweise

ORD-Eintrag
ord-960d209e97eb4111b6bd7889b0d46f0a
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08030500B2

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