4-Bromo-2,6-dimethylpyrimidine → 1-(3-Bromophenyl)-1-(2,6-dimethylpyrimidin-4-yl)-4-fluoro-1H-isoindol-3-amine
Reaktionsgleichung
Br[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([CH3:9])[N:3]=1.[Br:10][C:11]1[CH:12]=[C:13]([C:17]([C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([F:31])[C:26]=2[C:32]#[N:33])=[N:18]S(C(C)(C)C)=O)[CH:14]=[CH:15][CH:16]=1>>[Br:10][C:11]1[CH:12]=[C:13]([C:17]2([C:2]3[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([CH3:9])[N:3]=3)[C:25]3[C:26](=[C:27]([F:31])[CH:28]=[CH:29][CH:30]=3)[C:32]([NH2:33])=[N:18]2)[CH:14]=[CH:15][CH:16]=1Komponenten
3
Versuchsvorschrift
The title compound was synthesized as described for Example 35i in 35% yield, starting from of 4-bromo-2,6-dimethylpyrimidine (507 mg, 2.71 mmol) and N-((3-bromophenyl)(2-cyano-3-fluorophenyl)methylene)-2-methylpropane-2-sulfinamide (850 mg, 2.09 mmol). MS (ES+) m/z 411, 413 [M+H]+.
Quellen und Nachweise
- ORD-Eintrag