5-Iodo-2-methoxy-3-(trifluoromethyl)pyridine → 1-(3-Bromophenyl)-4-fluoro-1-(6-methoxy-5-(trifluoromethyl)pyridin-3-yl)-1H-isoindol-3-amine
Reaktionsgleichung
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[C:17]=2[C:23]#[N:24])=[N:9]S(C(C)(C)C)=O)[CH:5]=[CH:6][CH:7]=1.I[C:26]1[CH:27]=[C:28]([C:34]([F:37])([F:36])[F:35])[C:29]([O:32][CH3:33])=[N:30][CH:31]=1>>[Br:1][C:2]1[CH:3]=[C:4]([C:8]2([C:26]3[CH:31]=[N:30][C:29]([O:32][CH3:33])=[C:28]([C:34]([F:37])([F:36])[F:35])[CH:27]=3)[C:16]3[C:17](=[C:18]([F:22])[CH:19]=[CH:20][CH:21]=3)[C:23]([NH2:24])=[N:9]2)[CH:5]=[CH:6][CH:7]=1Komponenten
3
Versuchsvorschrift
The title compound was synthesized as described for Example 14i in 71% yield, starting from N-((3-bromophenyl)(2-cyano-3-fluorophenyl)methylene)-2-methylpropane-2-sulfinamide (815 mg, 2 mmol) and 5-iodo-2-methoxy-3-(trifluoromethyl)pyridine (606 mg, 2 mmol).