Methyl 3-(3-hydroxyphenyl)propionate → Methyl 3-(3-(((2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)propanoate

HRID 1662342Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1662342
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])[CH:5]=[CH:6][CH:7]=1.Cl[CH2:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[C:26]([O:28][CH3:29])[CH:25]=[CH:24][C:23]=2[F:30])=[C:18]([C:31]([CH3:34])([CH3:33])[CH3:32])[CH:17]=1>>[CH3:34][C:31]([C:18]1[CH:17]=[C:16]([CH2:15][O:1][C:2]2[CH:3]=[C:4]([CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])[CH:5]=[CH:6][CH:7]=2)[CH:21]=[CH:20][C:19]=1[C:22]1[CH:27]=[C:26]([O:28][CH3:29])[CH:25]=[CH:24][C:23]=1[F:30])([CH3:32])[CH3:33]

Komponenten

3

Edukt 2

HCID 1512675Methyl 3-(3-hydroxyphenyl)propionateHCID 577056714-(Chloromethyl)-2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl

Produkt 1

HCID 57706370Methyl 3-(3-(((2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)propanoateAusbeute 83 %

Versuchsvorschrift

Methyl 3-(3-hydroxyphenyl)propanoate (commercially available from Aagile Labs Division of Tyger Scientific) (0.025 g, 0.14 mmol) was alkylated by reaction with compound 8.10 (0.043 g, 0.14 mmol) according to the method given in Example 1 to give compound 34.1 as a clear oil (0.052 g, 83% yield). MS ESI (pos.) m/e: 473.2 (M+Na)+, 468.2 (M+H2O)+.

Quellen und Nachweise

ORD-Eintrag
ord-81fe2f87f75e4b97ad8da0aec0ee8f0d
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08030354B2

Notizen zur Reaktion

Wird geladen…