(3-Methoxyphenyl)boronic acid → 3-[3-(3'-Methoxy-2-trifluoromethoxy-biphenyl-4-ylmethoxy)-phenyl]-propionic acid
Reaktionsgleichung
Cl[C:2]1[CH:20]=[CH:19][C:5]([CH2:6][O:7][C:8]2[CH:9]=[C:10]([CH2:14][CH2:15][C:16]([OH:18])=[O:17])[CH:11]=[CH:12][CH:13]=2)=[CH:4][C:3]=1[O:21][C:22]([F:25])([F:24])[F:23].[CH3:26][O:27][C:28]1[CH:29]=[C:30](B(O)O)[CH:31]=[CH:32][CH:33]=1>>[CH3:26][O:27][C:28]1[CH:33]=[C:32]([C:2]2[CH:20]=[CH:19][C:5]([CH2:6][O:7][C:8]3[CH:9]=[C:10]([CH2:14][CH2:15][C:16]([OH:18])=[O:17])[CH:11]=[CH:12][CH:13]=3)=[CH:4][C:3]=2[O:21][C:22]([F:25])([F:24])[F:23])[CH:31]=[CH:30][CH:29]=1Komponenten
3
Versuchsvorschrift
Compound 37 was synthesized using the procedure above for preparing 13.3 using compound 37.3 and 3-methoxyphenylboronic acid 37.4 (available from Aldrich). MS ESI (neg.) m/e: 445 (M−H). 1H NMR (400 MHz, CD3CN) δ ppm 7.51 (3H, s), 7.38 (1H, s), 7.22 (1H, s), 7.05 (2H, s), 6.98 (1H, s), 6.87 (3H, s), 5.15 (2H, s), 3.81 (3H, s), 2.86 (2H, s), 2.59 (2H, s).
Quellen und Nachweise
- ORD-Eintrag
- ord-0d78d63d3c9b4c1e8b21181a2835e8e2