(3R)-3-(3-(((2-((1R)-2,2-Dimethylcyclopentyl)-3'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acid → Methyl 2-(2,2-dimethylcyclopentyl)-3'-(methyloxy)-1,1'-biphenyl-4-carboxylate

HRID 1662512Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1662512
CC1(C)CCC[C@@H:3]1[C:7]1C=C(COC2C=C([C@H](CC)CC(O)=O)C=CC=2)C=[CH:9][C:8]=1[C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([O:34][CH3:35])[CH:29]=1.[CH3:37][C:38]1([CH3:72])[CH2:42][CH2:41][CH2:40][C@H:39]1C1C=C(COC2C=C([C@H](CC)CC(O)=O)C=CC=2)C=CC=1C1C=CC=C(OC)C=1.CC1(C)CCC[C@@H]1C1C=C(COC2C=C([C@@H:93](CC)[CH2:94][C:95]([OH:97])=[O:96])C=CC=2)C=CC=1C1C=CC=C(OC)C=1.[CH3:109]C1(C)CCC[C@H]1C1C=C(COC2C=C([C@@H](CC)CC(O)=O)C=CC=2)C=CC=1C1C=CC=C(OC)C=1>>[CH3:72][C:38]1([CH3:37])[CH2:39][CH2:40][CH2:41][CH:42]1[C:9]1[CH:93]=[C:94]([C:95]([O:97][CH3:109])=[O:96])[CH:3]=[CH:7][C:8]=1[C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([O:34][CH3:35])[CH:29]=1

Komponenten

5

Edukt 4

HCID 57705561(3R)-3-(3-(((2-((1R)-2,2-Dimethylcyclopentyl)-3'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acidHCID 57705814(3S)-3-(3-(((2-((1S)-2,2-dimethylcyclopentyl)-3'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acidHCID 57706391(3R)-3-(3-(((2-((1S)-2,2-dimethylcyclopentyl)-3'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acidHCID 57707128(3S)-3-(3-(((2-((1R)-2,2-dimethylcyclopentyl)-3'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acid

Produkt 1

HCID 57706985Methyl 2-(2,2-dimethylcyclopentyl)-3'-(methyloxy)-1,1'-biphenyl-4-carboxylate

Versuchsvorschrift

(3R)-3-(3-(((2-((1S)-2,2-Dimethylcyclopentyl)-3′-(methyloxy)-1,1′-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acid or (3R)-3-(3-(((2-((1R)-2,2-dimethylcyclopentyl)-3′-(methyloxy)-1,1′-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acid or (3S)-3-(3-(((2-((1S)-2,2-dimethylcyclopentyl)-3′-(methyloxy)-1,1′-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acid or (3S)-3-(3-(((2-((1R)-2,2-dimethylcyclopentyl)-3′-(methyloxy)-1,1′-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acid (78.6). The title compound was prepared from chloromethyl compound 78.5F or 78.5G derived from 78.5D (peak one from the separation of the racemic alcohol) using the methods described herein. MS ESI (pos.) m/e: 504.2 (M+H2O)+, 509.2 (M+Na)+.

Aufarbeitung

  1. customfrom the separation of the racemic alcohol)

Quellen und Nachweise

ORD-Eintrag
ord-efb0e4b76ddb4cad9bf2cbc3b197d21e
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08030354B2

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