2-[5-chloro-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-N,N-dimethyl isoindoline-1-carboxamide → 2-(5-chloro-3-(2-methoxyphenyl)-1-{[4-methoxy-2-(trifluoromethoxy)phenyl]sulfonyl}-2-oxo-2,3-dihydro-1H-indol-3-yl)-N,N-dimethyl isoindoline-1-carboxamide

HRID 1662625Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1662625
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2([N:20]1[CH2:28][C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:21]1[C:29]([N:31]([CH3:33])[CH3:32])=[O:30])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH3:19].[CH3:34][O:35][C:36]1[CH:41]=[CH:40][C:39]([S:42](Cl)(=[O:44])=[O:43])=[C:38]([O:46][C:47]([F:50])([F:49])[F:48])[CH:37]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:42]([C:39]1[CH:40]=[CH:41][C:36]([O:35][CH3:34])=[CH:37][C:38]=1[O:46][C:47]([F:48])([F:49])[F:50])(=[O:44])=[O:43])[C:6](=[O:11])[C:5]2([N:20]1[CH2:28][C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:21]1[C:29]([N:31]([CH3:32])[CH3:33])=[O:30])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH3:19]

Komponenten

3

Edukt 2

HCID 181844802-[5-chloro-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-N,N-dimethyl isoindoline-1-carboxamideHCID 866256844-Methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride

Produkt 1

HCID 119516192-(5-chloro-3-(2-methoxyphenyl)-1-{[4-methoxy-2-(trifluoromethoxy)phenyl]sulfonyl}-2-oxo-2,3-dihydro-1H-indol-3-yl)-N,N-dimethyl isoindoline-1-carboxamide

Versuchsvorschrift

With 1.00 g of 2-[5-chloro-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-N,N-dimethyl isoindoline-1-carboxamide (diastereoisomer mixture), which is the compound described in Preparation 3.5 of the brochure Publication No. WO01/64668, and 692 mg of 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride as starting materials, 770 mg (Isomer mixture A, colorless amorphous) and 423 mg (Isomer mixture B, colorless amorphous) each of mixtures of diastereoisomers of the title compound were obtained by a similar method to Example 2.

Aufarbeitung

  1. customdescribed in Preparation 3.5 of the brochure Publication No

Quellen und Nachweise

ORD-Eintrag
ord-2e3f47efc615495f81cc14eb5b4f4fcd
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08030499B2

Notizen zur Reaktion

Wird geladen…