Hydrochloric Acid → (2S,4R)-4-hydroxy-N,N-dimethylpyrrolidine-2-carboxamide hydrochloride

HRID 1662684Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1662684
[CH3:1][N:2]([CH3:18])[C:3]([C@@H:5]1[CH2:9][C@@H:8]([OH:10])[CH2:7][N:6]1C(OC(C)(C)C)=O)=[O:4].[ClH:19]>CCOC(C)=O>[ClH:19].[OH:10][C@H:8]1[CH2:7][NH:6][C@H:5]([C:3]([N:2]([CH3:18])[CH3:1])=[O:4])[CH2:9]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 25180889(2S,4R)-tert-butyl 2-(dimethylcarbamoyl)-4-hydroxypyrrolidine-1-carboxylate

Produkt 1

HCID 23535508(2S,4R)-4-hydroxy-N,N-dimethylpyrrolidine-2-carboxamide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

To a solution of 11.0 g of the compound obtained in Step 88-1 in EtOAc (100 ml) was added dropwise a solution of 4 mol/l hydrochloric acid in EtOAc (100 ml) over 20 minutes. The solution was stirred at room temperature for two hours and then the solvent was evaporated under reduced pressure. EtOAc was added, and the solution was stirred for 30 minutes. Thereafter, the precipitated solid was filtered and then dried to obtain 8.21 g of the title compound (colorless solid).

Aufarbeitung

  1. customthe solvent was evaporated under reduced pressure
  2. additionEtOAc was added
  3. stirringthe solution was stirred for 30 minutes
  4. filtrationThereafter, the precipitated solid was filtered
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-2acaf965bcff49daa4c1497e3f458349
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08030499B2

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