Boc-hyp-obzl → Benzyl (4R)-4-hydroxy-L-prolinate--hydrogen chloride (1/1)

HRID 1662723Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1662723
[OH:1][C@H:2]1[CH2:6][N:5](C(OC(C)(C)C)=O)[C@H:4]([C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:15])[CH2:3]1.[ClH:24].CCOC(C)=O>CCOC(C)=O>[ClH:24].[OH:1][C@H:2]1[CH2:6][NH:5][C@H:4]([C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:15])[CH2:3]1

Komponenten

4

Edukt 2

HCID 11902907Boc-hyp-obzlHCID 21866389Hydrogen chloride-ethyl acetate

Produkt 1

HCID 16212860Benzyl (4R)-4-hydroxy-L-prolinate--hydrogen chloride (1/1)

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 10.0 g of the compound obtained in Step 157-1 in EtOAc (49 ml) was added a solution of 4 mol/L hydrochloric acid/EtOAc (39 ml). The solution was stirred at room temperature for one hour. The precipitated crystal was filtered, and the crystal was washed with EtOAc. The title compound in the amount of 6.70 g (colorless solid) was obtained.

Aufarbeitung

  1. filtrationThe precipitated crystal was filtered
  2. washthe crystal was washed with EtOAc

Quellen und Nachweise

ORD-Eintrag
ord-2e21f97ab35b4a2a86719cd1c48cdde5
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08030499B2

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