Triethylamine → N-(4-Methoxybenzylidene)glycine methyl ester

HRID 1662974Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1662974
Cl.[CH3:2][O:3][C:4](=[O:7])[CH2:5][NH2:6].C(N(CC)CC)C.[CH:15](=O)[C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1.[O-]S([O-])(=O)=O.[Mg+2]>C(Cl)Cl>[CH3:2][O:3][C:4](=[O:7])[CH2:5][N:6]=[CH:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1

Komponenten

6

Edukt 4

HCID 8471TriethylamineHCID 24083Sulfuric acid magnesium salt (1:1)HCID 312444-MethoxybenzaldehydeHCID 122755Glycine methyl ester hydrochloride

Produkt 1

HCID 4193973N-(4-Methoxybenzylidene)glycine methyl esterAusbeute 100,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To a solution of 77.46 g (0.617 mol) of glycine methylester hydrochloride in CH2Cl2, 92 ml (0.66 mol) of triethylamine, a solution of 60 g (0.44 mol) of p-anisaldehyde in 50 ml of CH2Cl2 and 40 g of MgSO4 are successively added at 0-5° C. under N2 atmosphere. After stirring for 18 h at r.t. the reaction mixture is filtered through celite and washed with CH2Cl2. The filtrate is concentrated under reduced pressure and then the crude mixture is diluted with AcOEt. The AcOEt solution is filtered again to remove triethylamine hydrochloride and the filtrate diluted with toluene and concentrated under reduced pressure (azeotropic removal of H2O) to give 91.3 g of [(4-methoxy-benzylidene)-amino]-acetic acid methyl ester as light yellow crystals; NMR (C6D6): 3.18 (s, 3H), 3.34 (s, 3H), 4.13 (s, 3H), 6.69 (d, 2H, J=8.56 Hz), 7.70 (d, 2H, J=8.56 Hz), 7.79 (s, 1H).

Aufarbeitung

  1. filtrationis filtered through celite
  2. washwashed with CH2Cl2
  3. concentrationThe filtrate is concentrated under reduced pressure
  4. additionthe crude mixture is diluted with AcOEt
  5. filtrationThe AcOEt solution is filtered again
  6. customto remove triethylamine hydrochloride
  7. additionthe filtrate diluted with toluene
  8. concentrationconcentrated under reduced pressure (azeotropic removal of H2O)

Quellen und Nachweise

ORD-Eintrag
ord-e4842009c52b48be9d630ada4f1709f1
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08034810B2

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