Hydrochloric Acid → 4-(1-Benzyl-piperidin-4-ylidenemethyl)-benzimidic acid ethyl ester

Beteiligte Stoffe

Reaktionsschritte

A mixture of 4-(1-benzyl-piperidin-4-ylidenemethyl)-benzonitrile (14 g, 48.6 mmol), chloroform (10 mL) and 6 M hydrogen chloride in ethanol (300 mL) was stirred at room temperature for 48 hours. The solution was concentrated in vacuo, the remaining solid was repeatedly dissolved in ethanol (400 mL) and concentrated in vacuo to yield 16.4 g (92.4%) of the title compound, which was used in the next steps without further purification.

Herkunft & Nachweise