3-Bromo-4-hydroxy-5-nitrobenzaldehyde → HCID 67435380, Verbindung

HRID 1663385Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1663385
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([N+:11]([O-:13])=[O:12])[C:9]=1[OH:10])[CH:5]=O.[CH3:14]/[C:15](/[NH2:19])=[CH:16]\[C:17]#[N:18].[CH2:20]([CH:23]1[CH2:28][C:27](=[O:29])[CH2:26][C:25](=O)[CH2:24]1)[CH2:21][CH3:22]>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:5]2[C:26]3[C:27](=[O:29])[CH2:28][CH:23]([CH2:20][CH2:21][CH3:22])[CH2:24][C:25]=3[NH:19][C:15]([CH3:14])=[C:16]2[C:17]#[N:18])[CH:7]=[C:8]([N+:11]([O-:13])=[O:12])[C:9]=1[OH:10]

Komponenten

5

Edukt 3

HCID 14943783-Bromo-4-hydroxy-5-nitrobenzaldehydeHCID 27372245-Propylcyclohexane-1,3-dioneHCID 53247203-Aminocrotonitrile

Produkt 1

HCID 67435380HCID 67435380, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A mixture of 3-bromo-4-hydroxy-5-nitro-benzaldehyde (18.26 g), 3-aminocrotonitrile (6.09 g) and 5-propylcyclohexane-1,3-dione (11.45 g) in ethanol (250 ml) was stirred at 80° C. for 17 h. The mixture was concentrated in vacuo. The residue was purified by chromatography on silicagel in dichloromethane as eluent.

Aufarbeitung

  1. concentrationThe mixture was concentrated in vacuo
  2. customThe residue was purified by chromatography on silicagel in dichloromethane as eluent

Quellen und Nachweise

ORD-Eintrag
ord-5ded5b8bd1f84c27b4dbc561ba532673
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08034945B2

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