HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Potassium Carbonate → N-[6-(5-amino-2-chlorophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 5-Amino-2-chlorophenol | HCID 80676 | — |
| Edukt | N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide | HCID 57386058 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | N-[6-(5-amino-2-chlorophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide | HCID 57505484 | 27% |
Reaktionsschritte
Using N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide (800 mg, 2.44 mmol), 5-amino-2-chlorophenol (422 mg, 2.93 mmol), potassium carbonate (843 mg, 6.1 mmol) and N,N-dimethylformamide (6.0 mL) as starting materials and in the same manner as in Example 91, the title compound (226 mg, 27%) was obtained as a brown solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08034812B2 |
| Quelldatensatz | uspto-grants-2011_10 |
| ORD ID | ord-833eaaa57ae34a1cbb68118e69ed66c2 |
| Quellennotiz | uspto-grants-2011_10 |