Ethyl Acetate → 5-Nitro-N-(2-oxo-ethyl)-isophthalamic acid methyl ester

HRID 1664208

Reaktionsgleichung

Reaktionsgleichung von HRID 1664208
[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:18]=[C:17]([N+:19]([O-:21])=[O:20])[CH:16]=[C:6]([C:7]([NH:9][CH2:10][CH:11](OC)[O:12]C)=[O:8])[CH:5]=1.C(OCC)(=O)C>C1COCC1.Cl>[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:18]=[C:17]([N+:19]([O-:21])=[O:20])[CH:16]=[C:6]([C:7]([NH:9][CH2:10][CH:11]=[O:12])=[O:8])[CH:5]=1

Komponenten

5

Edukt 2

HCID 8857Ethyl AcetateHCID 67439609N-(2,2-dimethoxy-ethyl)-5-nitro-isophthalamic acid methyl ester

Produkt 1

HCID 866265795-Nitro-N-(2-oxo-ethyl)-isophthalamic acid methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 29.7 g (95.1 mmol) of N-(2,2-dimethoxy-ethyl)-5-nitro-isophthalamic acid methyl ester in 300 ml of THF and 300 ml of 2N HCl is stirred overnight. Ethyl acetate is added, and the mixture is washed twice with brine. The organic phase is dried over sodium sulfate and evaporated to yield the product in the form of a yellow oil.

Aufarbeitung

  1. washthe mixture is washed twice with brine
  2. dry with materialThe organic phase is dried over sodium sulfate
  3. customevaporated
  4. customto yield the product in the form of a yellow oil

Quellen und Nachweise

ORD-Eintrag
ord-1612f793da6a4beda7e6ce3a5b6b8e03
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08039455B2

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