Trifluoroacetic acid → 9-pentyl-3-(trifluoromethyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one

HRID 1664549Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1664549
[CH2:1]([N:6]1[C:14]2[N:13]=[CH:12][NH:11][C:10]=2[C:9](=[O:15])[NH:8]/[C:7]/1=[N:16]\[NH2:17])[CH2:2][CH2:3][CH2:4][CH3:5].[F:18][C:19]([F:24])([F:23])[C:20](O)=O>>[CH2:1]([N:6]1[C:14]2[N:13]=[CH:12][NH:11][C:10]=2[C:9](=[O:15])[N:8]2[C:20]([C:19]([F:24])([F:23])[F:18])=[N:17][N:16]=[C:7]12)[CH2:2][CH2:3][CH2:4][CH3:5]

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 178446164HCID 178446164, Verbindung

Produkt 1

HCID 576003029-pentyl-3-(trifluoromethyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-oneAusbeute 60,2 %

Versuchsvorschrift

The mixture of (2E)-3-pentyl-3,7-dihydro-1H-purine-2,6-dione 2-hydrazone (200 mg, 0.85 mmol) in trifluoroacetic acid (10 mL) was refluxed overnight. The reaction mixture was concentrated and purified by preparative LCMS to yield the desired product (160 mg, 60.2%). LCMS calculated for C12H14F3N6O (M+H): 315.1. found 315.0.

Aufarbeitung

  1. temperaturewas refluxed overnight
  2. concentrationThe reaction mixture was concentrated
  3. custompurified by preparative LCMS

Quellen und Nachweise

ORD-Eintrag
ord-acc5a34b2e0548a1b00fa8d657fd011e
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08039478B2

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