HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium Carbonate → 2-chloro-N-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-benzenesulfonamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium Carbonate | HCID 10340 | — |
| Edukt | 3-(Methylsulfonyl)phenylboronic acid | HCID 2773542 | — |
| Edukt | N-(5-bromo-thiophen-2-ylmethyl)-2-chloro-benzenesulfonamide | HCID 35408985 | — |
| Katalysator | HCID 178418807 | HCID 178418807 | — |
| Lösungsmittel | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Produkt | 2-chloro-N-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-benzenesulfonamide | HCID 67440545 | — |
Reaktionsschritte
In analogy to example 1, step 3, N-(5-bromo-thiophen-2-ylmethyl)-2-chloro-benzenesulfonamide was reacted with (3-methylsulfonylphenyl)-boronic acid, Na2CO3 and dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct in dioxane/water to give 2-chloro-N-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-benzenesulfonamide as an off-white solid. MS: 440.3 ([M−H]−)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08039493B2 |
| Quelldatensatz | uspto-grants-2011_10 |
| ORD ID | ord-79f4bcc2eaba40baa0a925a2f2917474 |
| Quellennotiz | uspto-grants-2011_10 |