HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Benzoyl chloride → N-benzoyl-2-chloro-N-[2-(3-methanesulfonyl-phenyl)-thiazol-5-ylmethyl]-benzenesulfonamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Benzoyl chloride | HCID 7412 | — |
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | 2-chloro-N-[2-(3-methanesulfonyl-phenyl)-thiazol-5-ylmethyl]-benzenesulfonamide | HCID 67439913 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | N-benzoyl-2-chloro-N-[2-(3-methanesulfonyl-phenyl)-thiazol-5-ylmethyl]-benzenesulfonamide | HCID 25234388 | — |
Reaktionsschritte
In analogy to example 6, 2-chloro-N-[2-(3-methanesulfonyl-phenyl)-thiazol-5-ylmethyl]-benzenesulfonamide (example 10, step 2) was reacted with benzoyl chloride and N,N-diisopropyl ethyl amine in dichloromethane to give N-benzoyl-2-chloro-N-[2-(3-methanesulfonyl-phenyl)-thiazol-5-ylmethyl]-benzenesulfonamide as a colorless solid. MS: 548.7 ([M+H]+)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08039493B2 |
| Quelldatensatz | uspto-grants-2011_10 |
| ORD ID | ord-7b8b6e96da754115a68d0246a4745216 |
| Quellennotiz | uspto-grants-2011_10 |