HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Potassium Hydroxide → 3-(2',4',5'-Trifluoro-biphenyl-4-yloxymethyl)-benzoic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Potassium Hydroxide | HCID 14797 | — |
| Edukt | 3-(2',4',5'-Trifluoro-biphenyl-4-yloxymethyl)-benzoic acid methyl ester | HCID 67150368 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | 3-(2',4',5'-Trifluoro-biphenyl-4-yloxymethyl)-benzoic acid | HCID 58271190 | 93,2% |
Reaktionsschritte
3-(2′,4′,5′-Trifluoro-biphenyl-4-yloxymethyl)-benzoic acid methyl ester (2.9 g, 7.79 mmol) and 2N KOH (15.6 mL, 31.2 mmol) in 140 mL MeOH were reacted as above to yield 2.6 g (93.2%) of 3-(2′,4′,5′-trifluoro-biphenyl-4-yloxymethyl)-benzoic acid. LC-MS (ES) calculated for C20H13F3O3, 358.32; found m/z 357.1 [M−H]−.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08039495B2 |
| Quelldatensatz | uspto-grants-2011_10 |
| ORD ID | ord-609658ca5e9d4318a596d2c7c9fcae05 |
| Quellennotiz | uspto-grants-2011_10 |