Diethyl methylmalonate → 3-Methoxy-2-methyl-3-oxopropanoic acid

HRID 1665674

Reaktionsgleichung

Reaktionsgleichung von HRID 1665674
[OH-].[K+].[CH2:3]([O:5][C:6](=[O:14])[CH:7]([CH3:13])[C:8]([O:10]CC)=[O:9])C>CO>[CH3:3][O:5][C:6](=[O:14])[CH:7]([CH3:13])[C:8]([OH:10])=[O:9]

Komponenten

4

Edukt 2

HCID 11857Diethyl methylmalonateHCID 14797Potassium Hydroxide

Produkt 1

HCID 3006933-Methoxy-2-methyl-3-oxopropanoic acidAusbeute 47,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

KOH (386 mg, 6.88 mmol) was added to a solution 2-methyl-malonic acid diethyl ester (1 g, 5.74 mmol) in methanol (7 mL). The resulting mixture was stirred overnight at ambient temperature then concentrated. The resulting residue was diluted with water, acidified with conc. HCl and the product was extracted with dichloromethane. The organic layer was dried over sodium sulfate and concentrated under reduced pressure to afford 360 mg (47%) of 2-methyl-malonic acid monomethyl ester

Aufarbeitung

  1. concentrationthen concentrated
  2. additionThe resulting residue was diluted with water
  3. extractionthe product was extracted with dichloromethane
  4. dry with materialThe organic layer was dried over sodium sulfate
  5. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ffa459bab6874c01a1a05d203d9280f9
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08039463B2

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