[4-(4-{2-[6-Amino-8-methoxy-2-(2-methoxyethoxy)purin-9-yl]ethyl}-piperidin-1-ylmethyl)phenyl]methanol → 4-(4-{2-[6-Amino-8-methoxy-2-(2-methoxyethoxy)purin-9-yl]ethyl}-piperidin-1-ylmethyl)benzaldehyde

HRID 1666204Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1666204
[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][O:14][CH3:15])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([O:33][CH3:34])[N:6]2[CH2:16][CH2:17][CH:18]1[CH2:23][CH2:22][N:21]([CH2:24][C:25]2[CH:30]=[CH:29][C:28]([CH2:31][OH:32])=[CH:27][CH:26]=2)[CH2:20][CH2:19]1>[O-2].[O-2].[Mn+4].C(Cl)(Cl)Cl>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][O:14][CH3:15])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([O:33][CH3:34])[N:6]2[CH2:16][CH2:17][CH:18]1[CH2:23][CH2:22][N:21]([CH2:24][C:25]2[CH:26]=[CH:27][C:28]([CH:31]=[O:32])=[CH:29][CH:30]=2)[CH2:20][CH2:19]1

Komponenten

4

Edukt 1

HCID 59288029[4-(4-{2-[6-Amino-8-methoxy-2-(2-methoxyethoxy)purin-9-yl]ethyl}-piperidin-1-ylmethyl)phenyl]methanol

Produkt 1

HCID 592880284-(4-{2-[6-Amino-8-methoxy-2-(2-methoxyethoxy)purin-9-yl]ethyl}-piperidin-1-ylmethyl)benzaldehydeAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6212ChloroformLösungsmittel

Versuchsvorschrift

The compound (0.52 g, 1.10 mmol) obtained in Step (i) and manganese dioxide (0.95 g, 11.0 mmol) were added to chloroform (20 ml), and the mixture was stirred at room temperature for 15 hours. The mixture was filtered, and the filtrate was concentrated. The residue was purified by silica gel column (chloroform/methanol=100/1 to 50/1) to give the subtitle compound (0.47 g, 1.00 mmol) as a white solid. Yield: 92%.

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified by silica gel column (chloroform/methanol=100/1 to 50/1)

Quellen und Nachweise

ORD-Eintrag
ord-a92d55ffa30b49ef815a629de1aacc34
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08044056B2

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