1,1-Dimethoxyethyl(dimethyl)amine → (E)-1-(dimethylamino)ethylidenethiourea
Reaktionsgleichung
CO[C:3](OC)([N:5]([CH3:7])[CH3:6])[CH3:4].[NH2:10][C:11]([NH2:13])=[S:12]>C(Cl)Cl>[NH2:10][C:11](/[N:13]=[C:3](/[N:5]([CH3:7])[CH3:6])\[CH3:4])=[S:12]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
N,N-Dimethyl acetamide dimethyl acetal (75 g, 0.56 mole) was added to a suspension of thiourea (33.0 g, 0.43 mole) in methylene chloride. The mixture was heated under reflux for 4 h. The solvent was removed and the residue was crystallized from 5% MeOH and diethyl ether affording (1E)-N′-(aminocarbonothioyl)-N,N-dimethylethanimidamide (47.8 g, 76% yield).
Aufarbeitung
- temperatureThe mixture was heated
- temperatureunder reflux for 4 h
- customThe solvent was removed
- customthe residue was crystallized from 5% MeOH and diethyl ether
Quellen und Nachweise
- ORD-Eintrag
- ord-955c7a9935f041ab95c2b832f1d08e61
- Quelldatensatz
- uspto-grants-2011_10
- Patentnummer
- US08044062B2
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