Potassium Carbonate → 2-amino-8-ethyl-6-ethynyl-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one

HRID 1666274Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1666274
C(=O)([O-])[O-].[K+].[K+].[NH2:7][C:8]1[N:9]=[C:10]([CH3:27])[C:11]2[CH:17]=[C:16]([C:18]#[C:19][Si](C)(C)C)[C:15](=[O:24])[N:14]([CH2:25][CH3:26])[C:12]=2[N:13]=1>CO>[NH2:7][C:8]1[N:9]=[C:10]([CH3:27])[C:11]2[CH:17]=[C:16]([C:18]#[CH:19])[C:15](=[O:24])[N:14]([CH2:25][CH3:26])[C:12]=2[N:13]=1

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 576069742-amino-8-ethyl-4-methyl-6-((trimethylsilyl)ethynyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Produkt 1

HCID 576069672-amino-8-ethyl-6-ethynyl-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Potassium carbonate (1.00 g, 7.28 mmol) was added to a flask charged with 2-amino-8-ethyl-4-methyl-6-((trimethylsilyl)ethynyl)pyrido[2,3-d]pyrimidin-7(8H)-one (1.09 g, 3.64 mmol) in anhydrous methanol (15 mL). The reaction was stirred at room temperature under nitrogen for 16 h. The reaction was concentrated to one half volume and the yellow precipitate collected by vacuum filtration to afford 2-amino-8-ethyl-6-ethynyl-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one.

Aufarbeitung

  1. concentrationThe reaction was concentrated to one half volume
  2. filtrationthe yellow precipitate collected by vacuum filtration

Quellen und Nachweise

ORD-Eintrag
ord-d33964636b834db582cf1e66b7594515
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08044062B2

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