Acetyl chloride → alpha-Acetoxy-3,4,5-trimethoxyphenyl-acetic acid

HRID 1666297Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1666297
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[C:12]([O:16][CH3:17])[C:13]=1[O:14][CH3:15])[CH:6]([OH:10])[C:7]([OH:9])=[O:8].[C:18](Cl)(=[O:20])[CH3:19]>>[C:18]([O:10][CH:6]([C:5]1[CH:11]=[C:12]([O:16][CH3:17])[C:13]([O:14][CH3:15])=[C:3]([O:2][CH3:1])[CH:4]=1)[C:7]([OH:9])=[O:8])(=[O:20])[CH3:19]

Komponenten

3

Edukt 2

HCID 6367Acetyl chlorideHCID 139030963,4,5-Trimethoxymandelic acid

Produkt 1

HCID 67081678alpha-Acetoxy-3,4,5-trimethoxyphenyl-acetic acid

Versuchsvorschrift

3,4,5-Trimethoxymandelic acid (80.5 g) was treated with acetyl chloride (150 ml) at room temperature for three hours. The clear solution was concentrated to dryness under vacuum, and the oily residue was crystallized from toluene (280 ml) giving pure α-acetoxy-3,4,5-trimethoxyphenylacetic acid (80.9 g), m.p. 135-139° C.

Aufarbeitung

  1. concentrationThe clear solution was concentrated to dryness under vacuum
  2. customthe oily residue was crystallized from toluene (280 ml)

Quellen und Nachweise

ORD-Eintrag
ord-a59961e20d414f499f2b7ec6ebbb983a
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08044067B2

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