Potassium Carbonate → 2-(5-Bromo-2-chlorophenoxy)-5-(trifluoromethyl)pyridine

To a solution of 5-bromo-2-chlorophenol (1.5 g, 7.23 mmol) in DMF (6 mL) was added potassium carbonate (2.5 g, 18.07 mmol) at RT followed by 2-chloro-5-(trifluoromethyl)pyridine (1.3 g, 7.23 mmol) and the mixture was refluxed at 110° C. for 12 h. The reaction mixture was quenched with water and extracted with ethyl acetate three times. The total organic extract was washed with water and brine, dried over sodium sulfate and concentrated under reduced pressure to give the title compound (2.6 g, 100%). 1H NMR (500 MHz, CDCl3): δ 8.38 (s, 1H), 7.95 (d, J=6.5 Hz, 1H), 7.65 (s, 1H), 7.47 (d, J=2 Hz, 1H), 7.12 (m, 2H).

1. customThe reaction mixture was quenched with water
2. extractionextracted with ethyl acetate three times
3. extractionThe total organic extract
4. washwas washed with water and brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated under reduced pressure

ORD-Eintrag

ord-a972103174bb44d4a8b3708848301251

Quelldatensatz

uspto-grants-2011_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08044052B2