Chloroform → HCID 67445136, Verbindung

HRID 1666708

Reaktionsgleichung

Reaktionsgleichung von HRID 1666708
Cl.[NH2:2][CH2:3][CH:4]([CH3:9])[C:5]([O:7][CH3:8])=[O:6].C(Cl)(Cl)Cl.Cl[C:15]1[O:16][C:17]2[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=2[N:19]=1>>[CH3:8][O:7][C:5](=[O:6])[CH:4]([CH3:9])[CH2:3][NH:2][C:15]1[O:16][C:17]2[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=2[N:19]=1

Komponenten

4

Edukt 3

HCID 6212ChloroformHCID 119862-ChlorobenzoxazoleHCID 13063725Methyl 3-amino-2-methylpropanoate hydrochloride

Produkt 1

HCID 67445136HCID 67445136, VerbindungAusbeute 70,4 %

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

To the suspension of 0.55 g (4 mmol) methy 3-amino-2-methylpropionate hydrogen chloride salt and 4 ml chloroform 0.52 g (5.2 mmol) triethylamine and 0.3 g (2 mmol) 2-chloro-1,3-benzoxazole are added and the mixture is stirred at 40° C. for 4 hours and at room temperature for 12 hours. The chloroform solution is washed with water, citric acid solution and water, dried over sodium sulfate and evaporated in vacuum. The residue is treated with hexane, the crystals are filtered off and washed. 0.33 g title compound is obtained as white crystals. Mp: 89-90° C.

Aufarbeitung

  1. additionare added
  2. washThe chloroform solution is washed with water, citric acid solution and water
  3. dry with materialdried over sodium sulfate
  4. customevaporated in vacuum
  5. additionThe residue is treated with hexane
  6. filtrationthe crystals are filtered off
  7. washwashed

Quellen und Nachweise

ORD-Eintrag
ord-e6151e03b1cc4ccc8e0cef04df781c73
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08044078B2

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