HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Methylpiperazine → Olanzapine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-Methylpiperazine | HCID 53167 | — |
| Edukt | 2-(2-Aminoanilino)-5-methylthiophene-3-carbonitrile | HCID 67445262 | — |
| Produkt | Olanzapine | HCID 135398745 | — |
Reaktionsschritte
The process disclosed herein comprises reaction of 2-(2-aminoanilino)-5-methylthiophene-3-carbonitrile [10] with N-methylpiperazine in conjunction with N-methyl piperazine acid salt to give Olanzapine. The reaction is carried out at 90-138° C., preferably at 110-125° C. in 6-12 hours.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08044196B2 |
| Quelldatensatz | uspto-grants-2011_10 |
| ORD ID | ord-5e13e6863e2544d6bf3dbc3514595fe8 |
| Quellennotiz | uspto-grants-2011_10 |