(4aS,7aS)-tert-butyl 6-benzyloctahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate → (4aS,7aS)-tert-Butyl octahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate

HRID 1667112Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1667112
C([N:8]1[CH2:16][C@H:15]2[C@H:10]([N:11]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:12][CH2:13][CH2:14]2)[CH2:9]1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[N:11]1([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:12][CH2:13][CH2:14][C@H:15]2[CH2:16][NH:8][CH2:9][C@@H:10]12

Komponenten

4

Edukt 1

HCID 29973012(4aS,7aS)-tert-butyl 6-benzyloctahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate

Produkt 1

HCID 1519435(4aS,7aS)-tert-Butyl octahydro-1H-pyrrolo[3,4-b]pyridine-1-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

The product from Example 50A (0.15 g, 0.5 mmol) in methanol (80 mL) was hydrogenated (4 pounds per square inch) in the presence of palladium hydroxide on carbon (0.42 g) for 3 hours at room temperature. The reaction mixture was filtered and concentrated to yield the title compound. MS (DCI) m/z 227 (M+H)+.

Aufarbeitung

  1. customfor 3 hours
  2. customat room temperature
  3. filtrationThe reaction mixture was filtered
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-362870eaaf9c4d0dbb32ddfa06744e6a
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08044069B2

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