L-Phenylglycine → Tert-butyl (2s)-{[2-(4-{6-amino-5-[(4-fluorophenyl)carbonyl]-2-oxopyridin-1(2h)-yl}phenyl)ethyl]amino}(phenyl)ethanoate

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	L-Phenylglycine	HCID 99291	—
Edukt	Methanesulfonic acid 2-{4-[6-amino-5-(4-fluoro-benzoyl)-2-oxo-2H-pyridin-1-yl]-phenyl}-ethyl ester	HCID 58608538	—
Produkt	Tert-butyl (2s)-{[2-(4-{6-amino-5-[(4-fluorophenyl)carbonyl]-2-oxopyridin-1(2h)-yl}phenyl)ethyl]amino}(phenyl)ethanoate	HCID 57658465	—

Reaktionsschritte

From Intermediate 4J and L-Phenylglycine tbutyl ester. LC/MS: m/z 542 [M+H]+. 1H NMR (300 MHz, CDCl3) δ: 10.30 (1H, br s), 7.51-7.45 (3H, m), 7.38 (2H, d, J=6.9 Hz), 7.27-7.04 (9H, m), 5.82 (1H, d, J=9.6 Hz), 4.20 (1H, s), 2.86-2.75 (4H, m), 2.04 (1H, br s), 1.31 (9H, s).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08044211B2
Quelldatensatz	uspto-grants-2011_10
ORD ID	ord-1e827f433fd549eb9b02387ade5be87f
Quellennotiz	uspto-grants-2011_10