Hydrochloric Acid → (3-Aminomethyl-phenyl)-(2-morpholin-4-yl-ethyl)-amine hydrochloride

HRID 1667497Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1667497
C(OC(=O)[NH:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([NH:14][CH2:15][CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH:9]=1)(C)C.[ClH:24]>CO>[ClH:24].[NH2:6][CH2:7][C:8]1[CH:9]=[C:10]([NH:14][CH2:15][CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH:11]=[CH:12][CH:13]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 67415913[3-(2-Morpholin-4-yl-ethylamino)-benzyl]-carbamic acid isopropyl ester

Produkt 1

HCID 67416818(3-Aminomethyl-phenyl)-(2-morpholin-4-yl-ethyl)-amine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of [3-(2-morpholin-4-yl-ethylamino)-benzyl]-carbamic acid isopropyl ester (200 mg, 0.596 mmol), methanol (4 mL) and 4.89N isopropanolic hydrochloric acid (2.4 mL) was stirred at room temperature overnight. The reaction was concentrated and dried to yield (3-aminomethyl-phenyl)-(2-morpholin-4-yl-ethyl)-amine hydrochloride (212 mg) as an orange solid. m/z (M+1) 236.04.

Aufarbeitung

  1. concentrationThe reaction was concentrated
  2. customdried

Quellen und Nachweise

ORD-Eintrag
ord-d0461efb317140da8943833de944b134
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08044041B2

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