Methyl 2-(3,4-dimethoxyphenyl)-2-hydroxyacetate → Methyl 2-(2-fluoro-4,5-dimethoxyphenyl)-2-hydroxyacetate
Reaktionsgleichung
[F:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([O:12][CH3:13])=[CH:6][C:3]=1[CH:4]=[O:5].COC1C=C(C(O)[C:25]([O:27][CH3:28])=[O:26])C=CC=1OC>>[F:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([O:12][CH3:13])=[CH:6][C:3]=1[CH:4]([OH:5])[C:25]([O:27][CH3:28])=[O:26]Komponenten
3
Versuchsvorschrift
7A (1.05 g, 44%) was prepared in 2 steps from 2-fluoro-4,5-dimethoxybenzaldehyde following procedures analogous to the preparation of 6B. LC-MS: 267.11 (M+Na)+.
Quellen und Nachweise
- ORD-Eintrag
- ord-5fc53b28eedb4ff7981e5863cad4b791
- Quelldatensatz
- uspto-grants-2011_10
- Patentnummer
- US08044242B2
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