Cesium carbonate → 4-(3-Chloro-phenyl)-2-(5-dimethoxymethyl-2-nitro-phenylamino)-thiazole-5-carboxylic acid amide

Beteiligte Stoffe

Reaktionsschritte

A mixture of 2.56 g (11.9 mmole) of 4-dimethoxymethyl-2-fluoro-1-nitro-benzene (IV.2a), 3.00 g (11.85 mmole) of 2-amino-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid amide (V.2), 11.6 g (35.7 mmole) of cesium carbonate and 40 mL of dimethylformamide was stirred at 60 degrees for 3 hours. The mixture was cooled, poured into dilute ammonium chloride solution, and the precipitated yellow solid was collected by filtration, washed with water, and air-dried to give 4.43 g of 4-(3-chloro-phenyl)-2-(5-dimethoxymethyl-2-nitro-phenylamino)-thiazole-5-carboxylic acid amide (VI.2a).

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