Hydrogen chloride-ethyl acetate → 6-(4-chlorophenyl)-3-(2-{4-[(methylamino)methyl]phenyl}ethyl)thieno[3,2-d]pyrimidin-4(3H)-one dihydrochloride
Reaktionsgleichung
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:16][C:15]3[C:14](=[O:17])[N:13]([CH2:18][CH2:19][C:20]4[CH:35]=[CH:34][C:23]([CH2:24][N:25](C)[C:26](=O)OC(C)(C)C)=[CH:22][CH:21]=4)[CH:12]=[N:11][C:10]=3[CH:9]=2)=[CH:4][CH:3]=1.C(OCC)(=O)C.[ClH:42]>>[ClH:1].[ClH:42].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:16][C:15]3[C:14](=[O:17])[N:13]([CH2:18][CH2:19][C:20]4[CH:21]=[CH:22][C:23]([CH2:24][NH:25][CH3:26])=[CH:34][CH:35]=4)[CH:12]=[N:11][C:10]=3[CH:9]=2)=[CH:4][CH:3]=1Komponenten
3
Versuchsvorschrift
A mixture of the compound (0.18 g) obtained in Example 3 and 4N hydrogen chloride-ethyl acetate solution was stirred at room temperature for 1 hr. The solvent was evaporated under reduced pressure, and the residue was washed with ethyl acetate to give the title compound (0.17 g) as a colorless powder.
Aufarbeitung
- customThe solvent was evaporated under reduced pressure
- washthe residue was washed with ethyl acetate