Potassium Carbonate → n-(2,6-Dichlorobenzyl)-6-chloro-3-nitropyridin-2-amine

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a mixture of 2,6-dichloro-3-nitropyridine (1.0 g, 5.18 mmol) and potassium carbonate (848 mg, 6.14 mmol) in 15 mL MeCN was added 2,6-dichlorobenzylamine (0.63 mL, 5.18 mmol) at 0° C. The reaction mixture was stirred for one hour at 0° C. and then for 10 hours at room temperature. The organic solvent was evaporated and the residue was purified by silica gel chromatography (EtOAc:Hex=1:10) giving 16 [511 mg].

Herkunft & Nachweise