HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Potassium Carbonate → HCID 67341951, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | tert-Butyl (3S)-3-(aminomethyl)pyrrolidine-1-carboxylate | HCID 1514454 | — |
| Edukt | n-(2,6-Dichlorobenzyl)-6-chloro-3-nitropyridin-2-amine | HCID 59705189 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | HCID 67341951 | HCID 67341951 | 27,3% |
Reaktionsschritte
A mixture of 16 (100 mg, 0.34 mmol), (S)-tert-Butyl-3-(aminomethyl)pyrrolidine-1-carboxylate (0.4 g, 2.0 mmol), potassium carbonate (56.4 mg, 0.41 mmol) in 10 mL MeCN was stirred at reflux for 2 hours. The solvent was removed by vacuum and the residue was purified by silica gel chromatography (MeOH:DCM=1:10) giving 17 [46 mg, 27% yield].
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07989459B2 |
| Quelldatensatz | uspto-grants-2011_08 |
| ORD ID | ord-162a6e66d05144caa87ad93662f9af14 |
| Quellennotiz | uspto-grants-2011_08 |