5-Aminovaleric acid → Methyl 5-aminopentanoate hydrochloride

HRID 16696

Reaktionsgleichung

Reaktionsgleichung von HRID 16696
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]([OH:8])=[O:7].S(Cl)([Cl:11])=O.[CH3:13]O>>[ClH:11].[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]([O:8][CH3:13])=[O:7]

Komponenten

4

Edukt 3

HCID 1385-Aminovaleric acidHCID 887MethanolHCID 24386Thionyl Chloride

Produkt 1

HCID 13672034Methyl 5-aminopentanoate hydrochloride

Versuchsvorschrift

5-Aminovaleric acid (7.35 g) is dissolved in methanol (50 ml), and thereto is added dropwise thionyl chloride (4.9 ml) under ice-cooling. The reaction solution is then warmed to room temperature and stirred for 17 hours. The reaction solution is concentrated under reduced pressure. The resulting residue is suspended in diethyl ether and the precipitates are collected by filtration to give methyl 5-aminovalerate hydrochloride (9.93 g).

Aufarbeitung

  1. temperaturecooling
  2. concentrationThe reaction solution is concentrated under reduced pressure
  3. filtrationthe precipitates are collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-aa88e5f4b1ca45bfa1e9bb7a8dcca652
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07737161B2

Verknüpfte Notizen

Wird geladen…