Sulfuric Acid → HCID 86628493, Verbindung

HRID 1669650

Reaktionsgleichung

Reaktionsgleichung von HRID 1669650
[CH3:1][C:2]([NH:4][CH2:5][C@@H:6]1[O:11][C:9](=[O:10])[N:8]([C:12]2[CH:13]=[CH:14][C:15]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[C:16]([F:18])[CH:17]=2)[CH2:7]1)=[O:3].[S:25](=[O:29])(=[O:28])([OH:27])[OH:26]>C1COCC1>[CH3:1][C:2]([NH:4][CH2:5][C@@H:6]1[O:11][C:9](=[O:10])[N:8]([C:12]2[CH:13]=[CH:14][C:15]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[C:16]([F:18])[CH:17]=2)[CH2:7]1)=[O:3].[S:25]([O-:29])([O-:28])(=[O:27])=[O:26]

Komponenten

4

Edukt 2

HCID 1118Sulfuric AcidHCID 441401Linezolid

Produkt 1

HCID 86628493HCID 86628493, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

5 g of linezolid are dissolved at about 40° C. in 150 ml of THF. The solution is kept at about 40° C. and 0.85 ml of concentrated sulfuric acid (98% w/w H2SO4) are added, thus immediately causing linezolid sulfate to precipitate as a white solid. The mixture is refluxed, under stirring, for about 30 minutes, then left to cool first to room temperature then on an ice-water bath, stirring for about 30 minutes. A white solid precipitates, which is filtered with suction, washed with 5 ml of THF and dried under vacuum at about 50° C.

Aufarbeitung

  1. customis kept at about 40° C.
  2. customthus immediately causing linezolid sulfate to precipitate as a white solid
  3. temperatureThe mixture is refluxed
  4. waitleft
  5. stirringon an ice-water bath, stirring for about 30 minutes
  6. customA white solid precipitates
  7. filtrationwhich is filtered with suction
  8. washwashed with 5 ml of THF
  9. customdried under vacuum at about 50° C.

Quellen und Nachweise

ORD-Eintrag
ord-7fc8071c257844c5bffb6e3dcc67a1a0
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US07989618B2

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