Methyl morpholine oxide → 5-Chloro-2-methyl-4-oxo-4H-chromene-8-carbaldehyde

HRID 1669778Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1669778
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([CH:12](Br)Br)=[C:8]2[C:3]=1[C:4](=[O:16])[CH:5]=[C:6]([CH3:15])[O:7]2.C[N+]1([O-])CC[O:21]CC1>C(#N)C>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([CH:12]=[O:21])=[C:8]2[C:3]=1[C:4](=[O:16])[CH:5]=[C:6]([CH3:15])[O:7]2

Komponenten

4

Edukt 2

HCID 82029Methyl morpholine oxideHCID 574388935-chloro-8-(dibromomethyl)-2-methyl-4H-chromen-4-one

Produkt 1

HCID 574388945-Chloro-2-methyl-4-oxo-4H-chromene-8-carbaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

210 mg (0.57 mmol) of 5-chloro-8-(dibromomethyl)-2-methyl-4H-chromen-4-one are heated with 147 mg (1.2 mmol) of N-methylmorpholine N-oxide with the addition of molecular sieves in 15 ml of acetonitrile under reflux overnight. After filtration through kieselguhr, the solvent is removed in vacuo and the residue is purified by preparative HPLC. 22 mg (17% of theory) of the title compound are obtained.

Aufarbeitung

  1. temperatureunder reflux overnight
  2. filtrationAfter filtration through kieselguhr
  3. customthe solvent is removed in vacuo
  4. customthe residue is purified by preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-61f0625179394896a07f395e4e343a5d
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US07989633B2

Notizen zur Reaktion

Wird geladen…