Sodium Hydroxide → 3-Benzo[1,3]dioxol-5-yl-5-benzyloxy-benzoic Acid

HRID 1670075Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1670075
C[O:2][C:3](=[O:27])[C:4]1[CH:9]=[C:8]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:7]=[C:6]([C:18]2[CH:26]=[CH:25][C:21]3[O:22][CH2:23][O:24][C:20]=3[CH:19]=2)[CH:5]=1.[OH-].[Na+]>O1CCOCC1>[O:22]1[C:21]2[CH:25]=[CH:26][C:18]([C:6]3[CH:5]=[C:4]([CH:9]=[C:8]([O:10][CH2:11][C:12]4[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=4)[CH:7]=3)[C:3]([OH:27])=[O:2])=[CH:19][C:20]=2[O:24][CH2:23]1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 579059323-Benzo[1,3]dioxol-5-yl-5-benzyloxy-benzoic Acid Methyl Ester

Produkt 1

HCID 579058343-Benzo[1,3]dioxol-5-yl-5-benzyloxy-benzoic AcidAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

3-Benzo[1,3]dioxol-5-yl-5-benzyloxy-benzoic acid methyl ester (14.2 g) was dissolved in 1,4-dioxane (200 mL) and then 1 M aq. NaOH (40 mL) was added. The mixture was stirred at room temperature overnight. The solvents were removed under reduced pressure and the residue was diluted with water (200 mL). It was then made acidic by addition of 10% HCl (aq.) solution and the precipitated material was collected by filtration. The solid was washed with water and dried to yield 13.2 g (97% yield) of the title compound.

Aufarbeitung

  1. customThe solvents were removed under reduced pressure
  2. additionthe residue was diluted with water (200 mL)
  3. additionmade acidic by addition of 10% HCl (aq.) solution
  4. filtrationthe precipitated material was collected by filtration
  5. washThe solid was washed with water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-98aa8d1dc14548ef902dbda8b628317c
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US07989454B2

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