Hydrogen chloride-ethyl acetate → 1-(2-Thienyl)piperazine hydrochloride

HRID 1670744

Reaktionsgleichung

Reaktionsgleichung von HRID 1670744
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:15][CH:16]=[CH:17][CH:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:19].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:19].[S:15]1[CH:16]=[CH:17][CH:18]=[C:14]1[N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Komponenten

4

Edukt 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 673439001-Boc-4-(2-thienyl)piperazine

Produkt 1

HCID 231498111-(2-Thienyl)piperazine hydrochlorideAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

4-(2-Thienyl)piperazine-1-carboxylic acid tert-butyl ester (700 mg) was dissolved in ethyl acetate (4 ml), a 4N hydrochloric acid-ethyl acetate solution (4 ml) was added, and the mixture was stirred at room temperature for 1.5 hr. The precipitated solid was collected by filtration, washed with ethyl acetate and dried to give 1-(2-thienyl)piperazine hydrochloride (532 mg, yield 98%).

Aufarbeitung

  1. filtrationThe precipitated solid was collected by filtration
  2. washwashed with ethyl acetate
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-277e2fd057094455b0f702445eeefb32
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US07994196B2

Verknüpfte Notizen

Wird geladen…