Dimethylformamide → 2,4-Difluoro-5-iodobenzoyl chloride

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a solution of 11 (74.0 g, 260 mmol) in toluene (370 mL) was added thionyl chloride (95 mL, 1300 mmol) in DMF (2.5 mL, 26 mmol) and the mixture was heated to reflux for 4 h. The mixture was cooled to approximately 60° C. and filtered to remove insoluble material. The filtrate was concentrated under reduced pressure and residual thionyl chloride was co-evaporated with toluene (2×120 mL) to give crude 12 which was used without purification.

Herkunft & Nachweise