Methyl pyrimidine-4-carboxylate → 4-Pyrimidinecarboxylic acid

HRID 1671469

Reaktionsgleichung

Reaktionsgleichung von HRID 1671469
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][N:8]=[CH:7][N:6]=1)=[O:4].BrC1C(C(O)=S)=NC(C)=NC=1>[Ni]>[N:8]1[CH:9]=[CH:10][C:5]([C:3]([OH:4])=[O:2])=[N:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 254248Methyl pyrimidine-4-carboxylateHCID 178432654HCID 178432654, Verbindung

Produkt 1

HCID 1693064-Pyrimidinecarboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 935NickelKatalysator

Versuchsvorschrift

While J. Org. Chem., 30, 2398 (1965) describes that methylpyrimidine-4-carboxylate can be synthesized by treating 5-bromo-2-methylthiopyrimidine-4-carboxylic acid with Raney-nickel, as described in J. Chem. Soc., 1953, 3129, to give pyrimidine-4-carboxylic acid, and heating the obtained compound in methanol in the presence of concentrated hydrochloric acid. This method is problematic in the availability of the starting materials.

Aufarbeitung

  1. customcan be synthesized

Quellen und Nachweise

ORD-Eintrag
ord-d5a16c132df441b6816d964009780896
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US07994315B2

Verknüpfte Notizen

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