Methyl 2-fluoro-4-nitrobenzoate → Methyl 4-amino-2-fluorobenzoate

HRID 1671661Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1671661
[F:1][C:2]1[CH:11]=[C:10]([N+:12]([O-])=O)[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[H][H]>CO.O1CCCC1.[Ni]>[NH2:12][C:10]1[CH:9]=[CH:8][C:3]([C:4]([O:6][CH3:7])=[O:5])=[C:2]([F:1])[CH:11]=1

Komponenten

6

Edukt 2

HCID 3013872Methyl 2-fluoro-4-nitrobenzoateHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 21957875Methyl 4-amino-2-fluorobenzoate

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Methyl 2-fluoro-4-nitrobenzoate (141 mg) was dissolved in methanol (1000 ml) and tetrahydrofuran (400 ml), and Raney nickel (20 g) was added to it, and stirred overnight in a hydrogen atmosphere. The catalyst was removed through filtration, and the solvent was evaporated away under reduced pressure to obtain methyl 4-amino-2-fluorobenzoate.

Aufarbeitung

  1. customThe catalyst was removed through filtration
  2. customthe solvent was evaporated away under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-a0566c2eb2894387b636427eeefdb2ad
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US07994331B2

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