Methanol → HCID 131729111, Verbindung

Reaktionsgleichung

CO.C(N[C:12]1[CH:20]=[C:19](/[CH:21]=[CH:22]/[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[OH:29])[CH:18]=[CH:17][C:13]=1C(O)=O)(=O)C1C=CC=CC=1.[C:30]([O:33]CC)(=[O:32])C>[C].[Pd]>[OH:29][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=1[C:22]1[C:13]([CH2:12][CH3:20])=[C:17]([CH:18]=[CH:19][CH:21]=1)[C:30]([OH:33])=[O:32]

Komponenten

Versuchsvorschrift

12 mg of 5% palladium-carbon was added to a mixed solution of 1.5 mL of methanol and 1.5 mL of ethyl acetate containing 60 mg of 2-(benzamido)-4-((E)-2-(2-hydroxyphenyl)vinyl)benzoic acid and stirred under hydrogen atmosphere at room temperature for 3 hours and minutes. 6.0 mg of 5% palladium-carbon was added to the reaction mixture and stirred under hydrogen atmosphere at room temperature for 3 hours and 20 minutes. 6.0 mg of 5% palladium-carbon was added to the reaction mixture and stirred under hydrogen atmosphere at room temperature for 2 hours and 40 minutes. Insoluble were removed by filtration and the solvent was evaporated under reduced pressure. Diisopropyl ether was added to the obtained residue and a solid substance was separated by filtration to obtain 47 mg of 2-(benzamido)-4-(2-(2-hydroxyphenyl(ethyl)benzoic acid as white solid.