Tert-butyl 2-(2,3-dimethylbenzamido)-4-(4-(tert-butoxycarbonyl)oxyphenyl)benzoate → 2-(2,3-Dimethylbenzamido)-4-(4-hydroxyphenyl)benzoic acid

HRID 1673442Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1673442
[CH3:1][C:2]1[C:37]([CH3:38])=[CH:36][CH:35]=[CH:34][C:3]=1[C:4]([NH:6][C:7]1[CH:19]=[C:18]([C:20]2[CH:25]=[CH:24][C:23]([O:26]C(OC(C)(C)C)=O)=[CH:22][CH:21]=2)[CH:17]=[CH:16][C:8]=1[C:9]([O:11]C(C)(C)C)=[O:10])=[O:5]>FC(F)(F)C(O)=O>[CH3:1][C:2]1[C:37]([CH3:38])=[CH:36][CH:35]=[CH:34][C:3]=1[C:4]([NH:6][C:7]1[CH:19]=[C:18]([C:20]2[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=2)[CH:17]=[CH:16][C:8]=1[C:9]([OH:11])=[O:10])=[O:5]

Komponenten

3

Edukt 1

HCID 67342726Tert-butyl 2-(2,3-dimethylbenzamido)-4-(4-(tert-butoxycarbonyl)oxyphenyl)benzoate

Produkt 1

HCID 578794792-(2,3-Dimethylbenzamido)-4-(4-hydroxyphenyl)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(2,3-dimethylbenzamido)-4-(4-(tert-butoxycarbonyl)oxyphenyl)benzoate and stirred ah room temperature for 2 hours. The solvent was evaporated under reduced pressure and ethyl acetate was added to the obtained residue and a solid substance was separated by filtration to obtain 20 mg of 2-(2,3-dimethylbenzamido)-4-(4-hydroxyphenyl)benzoic acid as white solid.

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure and ethyl acetate
  2. additionwas added to the obtained residue
  3. customa solid substance was separated by filtration

Quellen und Nachweise

ORD-Eintrag
ord-a30d5ffaa6034487adc5abfb425a26eb
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US07999132B2

Notizen zur Reaktion

Wird geladen…