Methanol → HCID 57879314, Verbindung

HRID 1673453Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1673453
CO.[C:3]([NH:11][C:12]1[CH:20]=[C:19]([CH:21]2[CH2:25][CH2:24][CH:23]=[CH:22]2)[CH:18]=[CH:17][C:13]=1[C:14]([OH:16])=[O:15])(=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>[C].[Pd].C(OCC)(=O)C>[C:3]([NH:11][C:12]1[CH:20]=[C:19]([CH:21]2[CH2:25][CH2:24][CH2:23][CH2:22]2)[CH:18]=[CH:17][C:13]=1[C:14]([OH:16])=[O:15])(=[O:10])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Komponenten

5

Edukt 2

HCID 887MethanolHCID 57879367HCID 57879367, Verbindung

Produkt 1

HCID 57879314HCID 57879314, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

5.0 mg of 5% palladium-carbon was added to a mixed solution of 1.0 mL of methanol and 0.5 mL of ethyl acetate containing 25 mg of 2-(benzamido)-4-(2-cyclopenten-1-yl)benzoic acid and stirred at room temperature under hydrogen atmosphere for 7 hours and then at 40° C. for 8 hours and stirred at 45° C. for 15 hours. Insoluble were removed by filtration and the solvent was evaporated under reduced pressure. Methanol was added to the obtained residue and a solid substance was separated by filtration to obtain 16 mg of 2-(benzamido)-4-cyclopentyl benzoic acid as white solid.

Aufarbeitung

  1. waitat 40° C. for 8 hours
  2. stirringstirred at 45° C. for 15 hours
  3. customInsoluble were removed by filtration
  4. customthe solvent was evaporated under reduced pressure
  5. additionMethanol was added to the obtained residue
  6. customa solid substance was separated by filtration

Quellen und Nachweise

ORD-Eintrag
ord-78a3628595f74901b71bec602666574a
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US07999132B2

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