Tert-butyl 4-phenyl-2-(6-(piperidin-1-yl)pyridine-3-carboxamido)benzoate → 4-Phenyl-2-(6-(piperidin-1-yl)pyridine-3-carboxamido)benzoic acid

HRID 1673492Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1673492
[C:1]1([C:7]2[CH:19]=[CH:18][C:10]([C:11]([O:13]C(C)(C)C)=[O:12])=[C:9]([NH:20][C:21]([C:23]3[CH:24]=[N:25][C:26]([N:29]4[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]4)=[CH:27][CH:28]=3)=[O:22])[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>FC(F)(F)C(O)=O>[C:1]1([C:7]2[CH:19]=[CH:18][C:10]([C:11]([OH:13])=[O:12])=[C:9]([NH:20][C:21]([C:23]3[CH:24]=[N:25][C:26]([N:29]4[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]4)=[CH:27][CH:28]=3)=[O:22])[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

3

Edukt 1

HCID 67342967Tert-butyl 4-phenyl-2-(6-(piperidin-1-yl)pyridine-3-carboxamido)benzoate

Produkt 1

HCID 578793044-Phenyl-2-(6-(piperidin-1-yl)pyridine-3-carboxamido)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 4-phenyl-2-(6-(piperidin-1-yl)pyridine-3-carboxamido)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and water was added and pH was adjusted to pH 6.5 with a saturated sodium hydrogen carbonate aqueous solution. A solid substance was separated by filtration to obtain 56 mg of 4-phenyl-2-(6-(piperidin-1-yl)pyridine-3-carboxamido)benzoic acid as white solid.

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure and water
  2. additionwas added
  3. customA solid substance was separated by filtration

Quellen und Nachweise

ORD-Eintrag
ord-92698c583cc54eff8bbc1b18001b94d2
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US07999132B2

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