Tert-butyl 2-(2-acetoxybenzamido)-4-phenethylbenzoate → 2-(2-Hydroxybenzamido)-4-phenethylbenzoic acid

HRID 1673530Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1673530
C([O:4][C:5]1[CH:34]=[CH:33][CH:32]=[CH:31][C:6]=1[C:7]([NH:9][C:10]1[CH:22]=[C:21]([CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:20]=[CH:19][C:11]=1[C:12]([O:14]C(C)(C)C)=[O:13])=[O:8])(=O)C>FC(F)(F)C(O)=O>[OH:4][C:5]1[CH:34]=[CH:33][CH:32]=[CH:31][C:6]=1[C:7]([NH:9][C:10]1[CH:22]=[C:21]([CH2:23][CH2:24][C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:20]=[CH:19][C:11]=1[C:12]([OH:14])=[O:13])=[O:8]

Komponenten

3

Edukt 1

HCID 67341697Tert-butyl 2-(2-acetoxybenzamido)-4-phenethylbenzoate

Produkt 1

HCID 578793222-(2-Hydroxybenzamido)-4-phenethylbenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(2-acetoxybenzamido)-4-phenethylbenzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and 0.50 mL of methanol, 0.50 mL of tetrahydrofuran and 10 mg of potassium carbonate were added to the obtained residue sequentially and stirred at room temperature for 3 hours. After insoluble were removed by filtration, 3.0 mL of 10% citric acid aqueous solution was added and a solid; substance was separated, by filtration to obtain 11 mg of 2-(2-hydroxybenzamido)-4-phenethylbenzoic acid as white solid.

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure and 0.50 mL of methanol, 0.50 mL of tetrahydrofuran and 10 mg of potassium carbonate
  2. additionwere added to the obtained residue sequentially
  3. stirringstirred at room temperature for 3 hours
  4. customAfter insoluble were removed by filtration, 3.0 mL of 10% citric acid aqueous solution
  5. additionwas added
  6. customsubstance was separated, by filtration

Quellen und Nachweise

ORD-Eintrag
ord-c6074efba396494aa2dde26bd6388a96
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US07999132B2

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